5. #13 USC VS. UCLA

In one of the season’s top NCAA quarterback battles, USC’s Sam Darnold leads the top-15 Trojans into the Rose Bowl on a mission to cage Josh Rosen and the UCLA Bruins.

4. #5 LOUISVILLE VS. HOUSTON

Heading into Houston, quarterback Lamar Jackson and Louisville are looking to lock a major Bowl spot, but after last weekend’s upsets, Tom Herman’s Cougars could care less about the Cardinals’ ranking.

3. #23 FLORIDA VS. #16 LSU

After Hurricane Matthew postponed their October matchup, the Florida/LSU hype has only grown. Though outmanned, Jim McElwain’s Gators are more than ready for this better-late-than-never showdown in Baton Rouge. 

2. #9 OKLAHOMA VS. #14 WEST VIRGINIA

Quarterback Baker Mayfield commands the Sooner spotlight, but Oklahoma’s defense, namely its secondary, may pose the largest threat to the West Virginia Mountaineers in this prime-time Big 12 battle.

1. #10 COLORADO VS. #22 WASHINGTON STATE

In 2014, both Colorado and Washington State finished last in their divisions—in 2016, both are Pac-12 division leaders. Riding an eight-game win streak, Mike Leach’s Cougars look to keep the surprises coming against the top-ten Buffaloes.